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Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria.Today, even the most serious allergic reactions can be controlled effectively with non-sedating antihistamines without the risk of sedation.sedate - dignified and somber in manner or character and committed to keeping promises; "a grave God-fearing man"; "a quiet sedate nature"; "as sober as a judge"; "a solemn promise"; "the judge was solemn as he pronounced sentence"serious - concerned with work or important matters rather than play or trivialities; "a serious student of history"; "a serious attempt to learn to ski"; "gave me a serious look"; "a serious young man"; "are you serious or joking? Because the new class of non-sedating antihistamines is far more accurate than its predecessors in terms of targeting specific nerve cell receptors, there is a much lower incidence of non-sedating antihistamines binding to inappropriate cells, such as certain ones in the brain that are responsible for causing sedation when activated.Non-sedating antihistamines actually have the capacity to avoid them.They accomplished this by blocking the histamine from connecting with its receptors in specific nerve, muscle and glandular types of cells.There are some others as well that play a less significant role.

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Loratadine, 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester, 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester, loratadine (medication), 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, Ethyl Ester, loratadine, LORATADINE, Loratadine [Chemical/Ingredient], Loratadine product, Loratadine (product), Loratadine (substance)Zirtek, zyrtec [brand name], zirtek, zyrtec, Zyr TEC, Zyrtec, Pfizer Brand of Cetirizine Dihydrochloride, Pfizer Consumer Healthcare Brand of Cetirizine Dihydrochloride, Reactine, UCB Brand of Cetirizine Dihydrochloride, UCB Pharma Brand of Cetirizine Dihydrochloride, United Drug Brand of Cetirizine Dihydrochloride, Voltric A drug used to treat certain allergy symptoms.

This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.

Sedating antihistamines also have significant antimuscarinic activity and should be used with caution in patients with prostatic hypertrophy, urinary retention and angle-closure glaucoma.

Examples of sedating antihistamines: Sedation is rare with non-sedating antihistamines, however patients should be made aware that a sedative effect may occur and performance of skilled tasks such as operating machinery or driving maybe affected.

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